SURGICAL DISEASES, TRAUMATOLOGY, ORTHOPEDICS, UROLOGY : SARCOMA (SARСОМА) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
The etiology is not known. Known for the role of trauma.
The pathogenesis. Malignant tumor of nedifferencirovannaja and immature connective tissue elements, develops from fascia, tendons, muscle sheaths, the periosteum. There are sarcoma of immature and sarcoma of the Mature elements of connective tissue: fibreboard, chondro, mixo-, adeno - drives of the working systems and osteosarcoma. The tumor is growing extremely quickly, sprouting nearby tissue and forming metastases in the blood (especially in the lungs), rarely on the lymphatic system. By the nature of its forming cells there are round-cell sarcoma, ureteroureterostomy, giant cell. Among sarcomas of the bone distinguish misogeny (Central), originating from the bone marrow and periosteal (osteogenic), originating from the periosteum.
Symptoms. Fast growing, germinating surrounding dense tissue tumor in a single node or multiple nodes, sooner develops cachexia, sometimes severe pain. The destruction of the surrounding tissues, rapid and early development of metastases, recurrence rate characterize malignancy of the tumor. Cachexia develops only with the significant size of the tumor and especially during its collapse, often accompanied by a rise in temperature, animeseries, disorder of blood leukocytosis. When bone sarcomas first signs of pain in the bone with subsequent swelling and faster development (periosteal sarcoma). Due to the significant development of vascular sarcoma can sometimes pulsate.
For. Initially, the tumor grows, preventing significant violations of functions, but with the further growth and involvement in tumor nerve trunks can cause severe pain. Bone sarcoma, due to thinning of the bones, can lead to pathological fractures.
The recognition is based on the speed of growth, the lack of distinguishing tumor from the surrounding tissue. With the defeat of the bones of the characteristic x-ray picture: uneven destruction and resorption of the cortical layer with breakthrough tumor of the bone marrow cavity in soft tissue.
Early radical surgery. When separated bone sarcomas possible resection of the bone with bone grafting. The lymphosarcoma, round-cell sarcoma, giant cell misogeny sarcoma (sarcoma Jung) successfully treated with radiation therapy.