INFECTIOUS DISEASES : SODOKU (ILLNESS BITE RATS) (SODOKU) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
Etiology. The disease is caused by spirillum minus (1915). Pathogenic for humans, some monkeys, Guinea pigs, rats and mice.
Epidemiology. The spirochete found in humans, identical to the spirochete rats Carter (1881). Wild rats, spontaneously diabetic spirillum (1-3% infected)are the main reservoir of the virus. Ways of transmission from rat to rat and mechanism of human infection is through the bite of a rat is uncertain. It can be assumed that the infestation of rats, and infection of the mouth and teeth occur when eating dead rats. In the CIS countries and Russia illnesses random in nature. Especially it is widely distributed in Japan.
The pathogenesis is not understood. Important place of introduction of infection, as it is played in a number of pathologic processes necrosis inclusive. In addition to local changes, the result of OBDII spirilis flowing through the usual type of sequential attacks. Sodoku is fixing spiral in the skin and some skin symptoms.
Symptoms. Inflammation the quick already a place of a sting - rise of temperature with chills, severe headache, loss of consciousness, delirium, in rare cases, paresis, and paralysis. Enlargement of the regional glands. Exanthema arising at the place of introduction of infection and then spreading to the trunk.
For. The disease begins after 10 to 27 days after the introduction of infection. Simultaneously with the rise of temperature of pain and inflammation with limfangoita emanating from the site of the bite. Local effects are serous-hemorrhagic and sometimes necrotic in nature. Regional cancer increase. Exanthema in the form of bluish-purple spots appear at the place of introduction and spreading to the trunk. The first attack lasts 3 to 7 days, followed by pyrexia in 2 to 3 days, further attacks or short, or longer. The disease lasts for months and very exhausting sick. In some cases, there are common phenomena in other febrile seizures with the phenomena of lesions of the nervous system.
History and local changes at the site of the bite or scratch indicate the nature of the disease. Inoculation of the patient's blood into the peritoneal cavity of Guinea pigs and planting on Wednesday of Ungerman.
Repeated injections orally as tablets in doses of 0.3 - 0.45 with an interval of 5 to 7 days (3 - 4 injections). Penicillin 800 000 units per day (equal doses every 4 hours).