DISEASE OF THE ENDOCRINE GLANDS : PITUITARY-SUPRARENAL DISEASE (ITSENKO-CUSHING SYNDROME) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
Hyperfunction of the basophilic cells of the anterior lobe of the brain of the epididymis, usually basophilic adenoma with subsequent dysfunction of the adrenal glands, gonads and pancreas.
Symptoms. The disease mostly occurs in women, usually at a young age between 17 and 25 years. The face is full and round with acne, reddish color. The body and limbs are traces of multiple hemorrhages and areas of copper-red color. The obesity of the face, breast and abdomen; upper and lower limbs usually are not fat. In areas of highest concentration of fat, there are strips of red-purple scar character, the so-called striae distensae, similar to hyperemesis gravidarum. Hair falls out, and on parts of the body, where they commonly does not happen, there is an overgrowth, and women will have a mustache and beard. The sex glands are hypoplastic. Sexual feeling is reduced, menstrual periods become irregular, reduced and then completely stop. There was marked tendency to the development of furunculosis, phlegmon and fungal skin diseases. Headaches, drowsiness, poor memory, apathy. Characteristic is the increase of arterial blood pressure up to 200 mm and above, the emergence of early atheromatous vessels, diabetic carbohydrate metabolism, hyperglycemia, carbohydraturia, the rise of cholesterol in the blood. Often there are spontaneous bone fractures, most commonly ribs, bleeding in the skin, the retina, uterine, pulmonary and gastrointestinal bleeding. Complaints of pain in various parts of the body; the cause of pain in the spine are often changes in the vertebrae in the form of osteoporosis. Radiographically only occasionally detected destructive changes in the Turkish saddle because basophilic adenoma in contrast eosinophilic adenoma usually of small size. Reduced resistance to infections.
For. The disease develops slowly and only for 2 - 3 years reveals the full picture of the disease. Death may occur from bleeding in the brain from acute infections and septic diseases that patients are highly susceptible. In rare cases there is a stop and reverse the progression of the disease.
Recognition in clear-cut cases does not present great difficulties. In some cases it is necessary to carry out differential diagnosis with adrenal syndrome caused by a tumor (adenoma) of the cortex of the adrenal gland.
Prediction in most cases negative.
The use of drugs sex hormones: testosterone-propionate men follikulina and sinestrola women. Radiotherapy to the region of the pituitary gland. Symptomatic treatment. Surgical intervention.