DISEASE OF THE ENDOCRINE GLANDS : PITUITARY-SEXUAL DYSTROPHY (DYSTROPHIA ADIPO - SOGENITALIS) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
The disorder is based on pathological processes affecting how the brain appendage, and autonomic centers, laid on the bottom of the third ventricle: hemorrhage, thrombosis, embolism, inflammatory processes, tumors, formation of cysts, infectious diseases, tuberculosis, syphilis, abscesses in the brain appendage and in the vegetative centers of the bases of the third ventricle and the basal ganglia.
Symptoms. The disease is characterized by progressive obesity, hypoplasia of the external and internal genitalia, retardation of growth, if the disease has developed in childhood, and hypoplasia of the genital organs, if the disease has developed after puberty. Somnolence, mental lethargy, decreased basal metabolic rate, much fat belly, hips, buttocks, chest, shoulders. Limbs remain relatively thin. The fat layer in some patients, sensitive, under pressure and with the feeling gives the impression of a separate thick slices, laid in loose subcutaneous tissue. Belly hangs down in an apron. Especially characterized by thick folds of fat on the inner thighs. In men decreases sharply penis, testicles, prostate, disappears libido, comes azoospermia, stop erection and sexual intercourse becomes impossible. Women observed amenorea and loss of sexual feelings. If the disease develops in children, the sexual organs remain in the same condition in which they caught the disease, and secondary sexual characteristics do not develop. The skin is dry, pale, slightly yellowish, hair fall, the temperature is lowered, the border digestibility of carbohydrates commonly raised, sometimes joined phenomena diabetes. In many cases there is hypochromic anemia, a decrease in neutrophils, a relative increase of lymphocytes, monocytes and eosinophils. Complaints about headaches, General weakness, drowsiness, inefficiency. A pituitary tumor can cause loss of sensitivity to red and green color and the limitation of the field of view. Radiography is often an indication of changes in the structure of the Turkish saddle; the epiphyseal line of the skeleton a long time not ossify.
For usually long, if there is a malignant tumor of the pituitary gland.
Recognition is not difficult in cases of obesity, hypoplasia of the genital organs and changes from the Turkish saddle. At diagnosis it is necessary to exclude other types of obesity, myxedema and evnuhoidizm.
The prediction is usually unfavorable. In malignant brain tumors of the epididymis, it is always serious. If the basis of the disease is syphilis and timely specific treatment, it favorably.
Treatment in most cases is symptomatic. Substitution therapy pituitary preparations, nutritional, and physical therapy usually does not yield results. Temporary effect in the form of weight loss can sometimes be obtained from the use of thyroidin. Clearly the effect of specific therapy for syphilis etiology. In the presence of tumors or cysts of the pituitary radiotherapy or surgical treatment.