DISEASE OF THE ENDOCRINE GLANDS : HYPERGONADISM (HYPERGENITALISMUS) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
The basis of disease is increased functional activity of the gonads. Lesions of the genital glands, pineal gland, adrenal cortex, dropsy of the ventricles of the brain, encephalitis, etc. can serve as an etiological cause of the disease. Cases in which, along with premature puberty, there is accelerated General physical development mental retardations, the so-called macrogenitosomia leesah, often depend on the destruction of the endocrine glands. Cases in which there is premature development of sexual apparatus without power physical development, are in connection with the transferred cerebral diseases. Cases in which there is early puberty with simultaneous premature physical and mental development, so-called pubertas leesah, must be attributed to abnormal development of the growing organism.
Symptoms. Premature development of sexual organs, bones, muscles, the appearance of a mustache, beard, etc. boys, menstruation, breast enlargement and other girls.
The recognition. In cases of early puberty in boys, due to the development of malignant tumors of the testicles, there is an increase in the development of secondary sexual characteristics, and mental development is delayed sexual and physical; the development of early puberty in girls, due to the development of malignant ovarian tumors, characterized by the absence of the development of cachexia. With the development of early puberty on the basis of lesion of adrenal glands (mostly adenomas and adenocarcinomas) in girls develops pronounced virilism, or hirsutism, and the boys strongly developed musculature, sooner comes the epiphyseal ossification zones and rapid development of reproductive organs and secondary sexual characteristics. Mental development is delayed sexual and physical. Diagnosis made easier in cases when it is possible to determine the genital tumor or adrenal glands, or a tumor of the pineal gland with its distinctive focal phenomena from the side of the brain.
Prediction in most cases negative.
In all cases where defined tumor that causes the disease, you must delete it.