DISEASES OF THE BLOOD SYSTEM : PURPURA ANAPHYLACTOIDNA (HEMORRHAGIC PURPURA NERVOSA) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
This group includes the following diseases: purpura simplex, s purpura. peliosis rheumatica, purpura abdominalis, purpura fulminans.
Etiology and pathogenesis. Vascular toxicity anaphylactic origin, which are multiple hemorrhages in the skin and mucous membranes. Purpura while suffering exudative nature, it is often, papular and nodular appearance; resembles erythema. Often with purpura pours and urticaria, as a result you receive the itching.
Purpura simplex: after a short prodromal period accompanied by chills and fever, on the skin of the trunk abundantly poured petechiae, purpura. The spleen is slightly enlarged. 2, rarely 3 weeks, the disease can be cured.
Purpura rheumatica (peliosis rheumatica): rash purpura on the lower extremities accompanied by tenderness and swelling of the joints, resembling a picture of acute articular rheumatism. The spleen is enlarged, there is a thermal response. The disease is prone to relapses and remissions.
Purpura abdominalis: first symptoms side effects:gastrointestinal tract - abdominal pain, sometimes reaching such a significant extent that it can be assumed appendicitis, peritonitis and other acute diseases of the abdominal cavity; vomiting, bloody diarrhea. At the same time there is an acute nephritis with hematuria, in severe cases, bleeding in serous cavity (pleura and pericardium), as well as bleeding in the brain. Noted in some cases the transition from one clinical form to another.
Purpura fulminans occurs in children at an early age is under one year of life. Sudden onset of rapid fever, common hemorrhages on the skin in the form of purpura; mucous always clean. Serious condition and death during the first 2 days of illness. Haemorrhagic syndrome: normal bleeding time, normal or slightly increased platelet count, normal retraction blood clot, sharply positive symptom Konchalovsky.
For purpura abdominalis subacute, in separate attacks, lasting no more than 7 to 10 days with breaks in 5 - 7 days; sometimes affects the mathematical regularity of attacks (the role of the nervous system). After 4 - 5 attacks the patients without any treatment to get well. Most frequent in children, but this syndrome occurs in adults.
Recognition is not a problem.
The prediction is good (except purpura fulminans).