DISEASES OF THE BLOOD SYSTEM : MILOS CHRONIC MYELOSIS CHRONICA) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
Etiology and pathogenesis see Lymphedemas chronic.
Symptoms. Pain in the left hypochondrium (perisplenic), General weakness, tendency to bleeding, anemia. Draws attention to the sharp increase in the spleen (splenomegaly) at a relatively slight swelling of the external lymph glands various areas of the body (cervical, axillary), enlargement of the liver. Marked tenderness effleurage bones, sternum, ribs and spine. The skin and mucous membranes pale. Sometimes persistent diarrhea is the result of leukemic infiltration in the mucosa of the intestine. In urine the sharp increase in the excretion of uric acid crystals (a consequence of the disintegration of cells, whose nuclei contain nucleic acid), an increase in the excretion of phosphoric acid. Sometimes leukemia is accompanied by nephrosis. The number of leukocytes rarely more than a million per unit volume of blood, usually several hundred thousand in 1 mm3. Depending on the number of cells we can talk about leukemia, subleikemical and lakemicski form melosa. Qualitative disorders of the picture of the white blood cells characterized by the appearance of immature cells melodeo series - myeloblasts and their intermediate forms - Pro-and myelocytes; the number of young and rod-shaped with relatively normal also increased. Immature forms melodeo number does not exceed 40% of all common cellular forms of white blood. Reduced mainly lymphocytes. From the nervous system, in addition to adynamia, sometimes there are symptoms funicular melosa.
Course and complications. The disease is chronic, slowly progressive increase in symptoms. Among the complicating points should be noted infarctions of the spleen accompanied by perisplenitis, susceptibility to hemorrhagic diateza (nasal bleeding from gums, purpura, bruising). The development of anemia is associated with increased phenomena hemorrhagic diathesis, and metabolic disorders. The exacerbation of the disease is accompanied by a temperature rise type continua, enlarged spleen, increased diathesis, rejuvenation of blood, a sharp increase in immature forms melodeo series (up to 70 - 80%) and progressive cachexia.
Recognition is difficult in the presence of alakamisy or subleikemical forms melosa. To differentsirovat have with different clinical forms of anemia.
The prediction is in close connection with the nature of the flow and stage of the disease. Short-term remission is often influenced by treatment. Prognosis worsens when attaching events hemorrhagic diathesis and when moving in the subacute form, and in the presence of complicating the course of diseases such as pneumonia, malaria, tuberculosis of the lungs.
Treatment is essentially a progressive suppression of proliferation foci melodey metaplasia in various organs. General and local irradiation of the spleen, bones, and lymph nodes of x-rays. Properly to start with irradiation of the spleen on some fields. X-ray treatments should
Treatment is essentially a progressive suppression of proliferation foci melodey metaplasia in various organs. General and local irradiation of the spleen, bones, and lymph nodes of x-rays. Properly to start with irradiation of the spleen on some fields. X-ray treatments should be under the control of blood tests; better fractional irradiation - 2 - 3 sessions, followed by a pause in 5 - 7 days. In addition to the hematological parameters should take into account the nature of the reaction of the whole organism of the patient to x-ray treatments. Sometimes after the first session there is a severe reaction with fever, severe fever, headaches, vomiting. In such cases, the intervals between sessions of several days is required. Contraindication to the prescription of x-rays are feverish forms of chronic milose - subacute leukemia and sharp anemicare patient. Rational to start the treatment of x-rays in a more Mature stage of the disease (in a year or two after clinically recognized early leukemia); before this period, it is appropriate to use other methods of treatment of leukemia. Patients who have been previously radiotherapy, much worse treatable by other methods, as under the influence of therapy in the patient with leukemia irreversible change from a number of bodies (the destruction of the delicate tissues of a number of parenchymatous organs and its replacement by connective tissue). Overdose leads to the transition to the chronic form in subacute flowing leukemia. And medication.