DISEASES OF THE BLOOD SYSTEM : LYMPHEDEMAS CHRONIC (LYMPHADENOSIS CHRONICA) - etiology, pathogenesis, symptoms and course of, recognition, prediction and prevention
The etiology is unknown: Among provoking the disease factors it should be noted infection (sepsis)and rarely injured.
The pathogenesis. Leukemia is a systemic or generalized disease characterized by hyperplastic tumor process in the field lamblasting apparatus. When pumping Melodey tissue development is observed melosa, when the distribution process hyperplasia among lymphatic tissue - developing lymphatic leukemia (lymphadenosis). When milose foci of hematopoiesis (Meloidae metaplasia) localized mainly in the spleen (splenomegaly), bone marrow, liver; less they are expressed in the lymphatic glands and the kidneys. When lymphadenopa (lymphoid metaplasia) they are concentrated mainly in the lymph glands, spleen, bone marrow, and liver. In General education uncustomary foci of hematopoiesis (metaplasia) inherent in any form of leukemia and may occur in any part of the body where there are cells of the mesenchyme, capable of hematopoiesis. Among the various forms of leukemia are observed transitions from pure hyperplasia to neoplastic growth - hence the definition of the leukaemic process as hemoblastosis (neoplastic growth of hematopoietic tissue).
Symptoms. General weakness, a sharp increase in external lymph glands (especially the neck, armpit, groin and other areas of the body) at a relatively slight enlargement of the spleen. Cancer is not soldered between each other, movable, it is not painful to palpation, plotnosty. Spleen enlarged; usually she speaks on a 6 to 8 cm from under the edges of the ribs; the liver also increased. Sometimes there lymphoma of the skin (usually on the face), along with this, the skin is often prone to nonspecific processes (eczema, urticaria). In the urine sometimes detect the elevated levels of uric acid. Depending on the localization of lymphatic hyperplasia observed and various syndromes. If painful process included mediastinal gland syndrome mediastinal tumors; when the concentration process in the mesenteric glands predominate symptoms and bowel. Red blood: in the early stages of moderate anemia, more progressive anemia reaches a sharp degree. From white blood cells there is an increase in the number of leukocytes, or moderate to 20,000 (alakamisy form lymphadenopa), or from 20 000 to 60 000 (subleikemical lymphedemas), or, finally, to a few hundreds of thousands, and sometimes more than a million (leukemia lymphedemas). In the leukocyte formula noted relative and absolute decrease in the percentage of all types of leukocytes due to the increase of lymphocytes. Dominated by small largest lymphocytes; there are often atypical lymphocytes with bare nuclei, immature mother cells (lymphoblasts), on the contrary, large, loose chromatin network core, painted in lighter than in normal lymphocytes; sometimes there are lymphocytes with his kernel, Taurus Botkin - Gumprecht - destroyed lymphocytes with blurred outlines the core and, finally, a single plasma cells.
The disease is quite favorable; there are known cases with a lifetime of up to 10 - 15 went, especially when alakamisy lymphadenopa.
R e s p o C h I n g is based on the above.
Prediction serious; lymphedemas though imperceptibly, but still progressing; usually anemia worsens, symptoms characteristic of hemorrhagic diateza, and patients with symptoms of progressive cachexia die. The accession of infection (sepsis) worsens the prognosis.
The radiotherapy. Irradiation of X-rays is subjected in a known sequence, spleen, lymph glands, bone, and also carry out General irradiation. The best effect is achieved with a combination of General and local irradiation. Strict control of blood is absolutely necessary; based on his data, it is appropriate to make certain adjustments in the treatment regimen: setting frequency radiation sessions, compliance with pauses between them. Arsenic and urethane more effective in the early stage of the disease. It is recommended that benzene (caution): strict control of the blood, kidneys and overall patient response to treatment with benzene. A blood transfusion is appropriate only in those cases where anemia is particularly pronounced; appointed as iron supplements, liver diet. In milder forms of chronic lymphadenopa shown sanatorium-resort treatment in Kislovodsk, Zheleznovodsk.